The dorsal horn (DH) of the spinal cord is an important structure involved in the integration of nociceptive messages.Plastic changes in the properties of neuronal networks in the DH underlie the development of analgesia as well as of hyperalgesia and allodynia in acute and chronic pain states.Two key mechanisms are involved in these chronic pain s
Immune checkpoint inhibitors (ICIs) are increasingly being used to manage multiple tumor types.Unfortunately, immune-related adverse mqr93ll/a events affect up to 60% of recipients, often leading to treatment discontinuation in settings where few alternative cancer therapies may be available.Checkpoint inhibitor induced colitis (ICI-colitis) is a c
Humanity pituitary gland in spanish may be thought of as a vernacular house of handmade rooms, some shackled, some finely crafted, some patched and repurposed and some clean and empty, waiting.Some spaces have high ceilings filled with music that echoes off stone walls or wooden planks; some are warm with familiar smells of boneflesh d2 bread bakin
The Salinas-Los Hoyos karst system is a geological diapiric structure formed by materials of diverse nature (clays, sandstones, evaporites, volcanic rocks, dolostones, etc.) placed between Malaga and Granada provinces (S Spain).The abundance of evaporite rocks (gypsum, anhydrite and halite) and their high solubility contribute to the development of